Background：Heterotrimeric guanine nucleotide-binding proteins （G proteins）, which integrate signals between receptors and effector proteins, are composed of an alpha, a beta, and a gamma subunit. These subunits are encoded by families of related genes. This gene encodes a beta subunit which belongs to the WD repeat G protein beta family. Beta subunits are important regulators of alpha subunits, as well as of certain signal transduction receptors and effectors. A single-nucleotide polymorphism （C825T） in this gene is associated with essential hypertension and obesity. This polymorphism is also associated with the occurrence of the splice variant GNB3-s, which appears to have increased activity. GNB3-s is an example of alternative splicing caused by a nucleotide change outside of the splice donor and acceptor sites. Alternative splicing results in multiple transcript variants. Additional alternatively spliced transcript variants of this gene have been described, but their full-length nature is not known.
仕様
Synonyms：G protein beta 3 subunit,GBB3,GNB3,GNB3 guanine nucleotide binding protein （G protein）, beta polypeptide 3,GTP binding regulatory protein beta 3 chain,Guanine nucleotide binding protein （G protein） beta polypeptide 3,Guanine nucleotide binding protein G,Guanine nucleotide binding protein G（I）/G（S）/G（T） beta subunit 3,Guanine nucleotide-binding protein G（I）/G（S）/G（T） subunit beta-3,Hypertension associated protein,IG,SG,Transducin beta chain 3,Tsubunit beta 3
Host：Rabbit
Reactivity：Mouse,Rat
Applications：WB
Concentration：1mg/ml
Immunogen：Recombinant protein of human GNB3
Purification Method：Affinity purification
Clonality：Polyclonal
Conjugation：Unconjugated
Buffer：Buffer： PBS with 0.02％ sodium azide, 50％ glycerol, pH7.3.
Dilution：WB1：500 - 1：2000
Gene_ID（human）：2784
Swissprot：P16520
Isotype：IgG
Research Areas：Cancer, Cardiovascular, Metabolism, Neuroscience, Signal transduction
