Background：This gene encodes the enzyme responsible for the excision of 8-oxoguanine, a mutagenic base byproduct which occurs as a result of exposure to reactive oxygen. The action of this enzyme includes lyase activity for chain cleavage. Alternative splicing of the C-terminal region of this gene classifies splice variants into two major groups, type 1 and type 2, depending on the last exon of the sequence. Type 1 alternative splice variants end with exon 7 and type 2 end with exon 8. All variants share the N-terminal region in common, which contains a mitochondrial targeting signal that is essential for mitochondrial localization. Many alternative splice variants for this gene have been described, but the full-length nature for every variant has not been determined.
仕様
Synonyms：8 hydroxyguanine DNA glycosylase,8 oxoguanine DNA glycosylase 1,8 oxoguanine DNA glycosylase,AP lyase,DNA （apurinic or apyrimidinic site） lyase,DNA apurinic or apyrimidinic site lyase,DNA lyase,DNA-（apurinic or apyrimidinic site） lyase,HMMH,HOGG 1,HOGG1,MMH,MUTM,N glycosylase,Ogg 1,Ogg1,OGG1,OGH 1,OGH1
Host：Rabbit
Reactivity：Human,Mouse,Rat
Applications：WB,IHC
Concentration：1mg/ml
Immunogen：Recombinant protein of human OGG1
Purification Method：Affinity purification
Clonality：Polyclonal
Conjugation：Unconjugated
Buffer：Buffer： PBS with 0.02％ sodium azide, 50％ glycerol, pH7.3.
Dilution：WB1：500 - 1：2000 IHC1：50 - 1：200
Gene_ID（human）：4968
Swissprot：O15527
Isotype：IgG
Research Areas：Cancer, Epigenetics and Nuclear Signaling
