Background：This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein localizes to the endoplasmic reticulum. It has both 17alpha-hydroxylase and 17,20-lyase activities and is a key enzyme in the steroidogenic pathway that produces progestins, mineralocorticoids, glucocorticoids, androgens, and estrogens. Mutations in this gene are associated with isolated steroid-17 alpha-hydroxylase deficiency, 17-alpha-hydroxylase/17,20-lyase deficiency, pseudohermaphroditism, and adrenal hyperplasia.
仕様
Synonyms：20 lyase,CP17A,CPT7,CYP17,CYP17A1,CYPXVII,Cytochrome P450 17A1,Cytochrome P450 family 17,Cytochrome P450 family 17 subfamily A polypeptide 1,Cytochrome p450 subfamily XVII （steroid 17 alpha hydroxylase） adrenal hyperplasia,Cytochrome p450 XVIIA1,Cytochrome P450-C17,Cytochrome P450c17,OTTHUMP00000020382,P450 C17,P450c17,S17AH,Steroid 17 alpha hydroxylase/17,20 lyase,Steroid 17 alpha monooxygenase,Steroid 17-alpha-hydroxylase/17,Steroid 17-alpha-monooxygenase
Host：Rabbit
Reactivity：Human,Mouse
Applications：WB
Concentration：1mg/ml
Immunogen：Recombinant protein of human CYP17A1
Purification Method：Affinity purification
Clonality：Polyclonal
Conjugation：Unconjugated
Dilution：WB1：500 - 1：2000
Gene_ID（human）：1586
Swissprot：P05093
Isotype：IgG
Research Areas：Cancer, Cardiovascular, Metabolism, Signal transduction
