Background：Mammalian lens crystallins are divided into alpha, beta, and gamma families. Alpha crystallins are composed of two gene products： alpha-A and alpha-B, for acidic and basic, respectively. Alpha crystallins can be induced by heat shock and are members of the small heat shock protein （HSP20） family. They act as molecular chaperones although they do not renature proteins and release them in the fashion of a true chaperone; instead they hold them in large soluble aggregates. Post-translational modifications decrease the ability to chaperone. These heterogeneous aggregates consist of 30-40 subunits; the alpha-A and alpha-B subunits have a 3：1 ratio, respectively. Two additional functions of alpha crystallins are an autokinase activity and participation in the intracellular architecture. The encoded protein has been identified as a moonlighting protein based on its ability to perform mechanistically distinct functions. Alpha-A and alpha-B gene products are differentially expressed; alpha-A is preferentially restricted to the lens and alpha-B is expressed widely in many tissues and organs. Elevated expression of alpha-B crystallin occurs in many neurological diseases; a missense mutation cosegregated in a family with a desmin-related myopathy. Alternative splicing results in multiple transcript variants.
仕様
Synonyms：AACRYA,Alpha B crystallin,Alpha crystallin B chain,Alpha（B）-crystallin,Alpha-crystallin B chain,CRYA2,Cryab,CRYAB,Crystallin alpha B,Crystallin alpha polypeptide 2,CTPP2,Heat shock 20 kD like protein,Heat shock protein beta 5,Heat shock protein beta-5,HspB5,Renal carcinoma antigen NY REN 27,Renal carcinoma antigen NY-REN-27,Rosenthal fiber component
Host：Rabbit
Reactivity：Human,Mouse,Rat
Applications：WB
Concentration：1mg/ml
Immunogen：Recombinant protein of human CRYAB
Purification Method：Affinity purification
Clonality：Polyclonal
Conjugation：Unconjugated
Buffer：Buffer： PBS with 0.02％ sodium azide, 50％ glycerol, pH7.3.
Dilution：WB1：500 - 1：2000
Gene_ID（human）：1410
Swissprot：P02511
Isotype：IgG
Research Areas：Cancer, Metabolism, Neuroscience, Signal transduction
