Background：CpG methylation is an epigenetic modification that is important for embryonic development, imprinting, and X-chromosome inactivation. Studies in mice have demonstrated that DNA methylation is required for mammalian development. This gene encodes a nuclear protein with similarity to DNA methyltransferases, but is not thought to function as a DNA methyltransferase as it does not contain the amino acid residues necessary for methyltransferase activity. However, it does stimulate de novo methylation by DNA cytosine methyltransferase 3 alpha and is thought to be required for the establishment of maternal genomic imprints. This protein also mediates transcriptional repression through interaction with histone deacetylase 1. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.
仕様
Synonyms：Cytosine 5 methyltransferase 3 like protein,DNA （cytosine 5 ） methyltransferase 3 like,DNA （cytosine-5）-methyltransferase 3-like,DNA cytosine 5 methyltransferase 3 like protein,DNA methyltransferase 3 like protein,DNM3L,Dnmt 3L,Dnmt3l,Human cytosine 5 methyltransferase 3 like protein,MGC1090
Host：Rabbit
Reactivity：Human,Mouse,Rat
Applications：WB
Concentration：1mg/ml
Immunogen：Recombinant protein of human DNMT3L
Purification Method：Affinity purification
Clonality：Polyclonal
Conjugation：Unconjugated
Buffer：Buffer： PBS with 0.02％ sodium azide, 50％ glycerol, pH7.3.
Dilution：WB1：500 - 1：2000
Gene_ID（human）：29947
Swissprot：Q9UJW3
Isotype：IgG
Research Areas：Cancer, Epigenetics and Nuclear Signaling
