Background：This gene encodes a member of the aldo/keto reductase superfamily, which consists of more than 40 known enzymes and proteins. These enzymes catalyze the conversion of aldehydes and ketones to their corresponding alcohols by utilizing NADH and/or NADPH as cofactors. The enzymes display overlapping but distinct substrate specificity. This enzyme catalyzes the reduction of prostaglandin （PG） D2, PGH2 and phenanthrenequinone （PQ）, and the oxidation of 9alpha,11beta-PGF2 to PGD2. It may play an important role in the pathogenesis of allergic diseases such as asthma, and may also have a role in controlling cell growth and/or differentiation. This gene shares high sequence identity with three other gene members and is clustered with those three genes at chromosome 10p15-p14. Three transcript variants encoding different isoforms have been found for this gene.
仕様
Synonyms：17 beta HSD 5,17 beta hydroxysteroid dehydrogenase type 5,17-beta-HSD 5,17-beta-hydroxysteroid dehydrogenase type 5,2-dihydrobenzene-1,2-diol dehydrogenase,20-alpha-hydroxysteroid dehydrogenase,3 alpha hydroxysteroid dehydrogenase type II,3-alpha-HSD type 2,3-alpha-HSD type II,3-alpha-HSD type II,brain,3-alpha-hydroxysteroid dehydrogenase type 2,AK1C3,AKR1 C3,Akr1c18,AKR1C3,Aldo keto reductase family 1 member C3,Aldo-keto reductase family 1 member C3,brain,Chlordecone reductase,Chlordecone reductase homolog HAKRb,DD-3,DD3,DDH1,DDX,Dihydrodiol dehydrogenase 3,Dihydrodiol dehydrogenase type I,Dihydrodiol dehydrogenase X,HA1753,HAKRB,HAKRe,hluPGFS,HSD17B5,Indanol dehydrogenase,KIAA0119,PGFS,Prostaglandin F synthase,Testosterone 17-beta-dehydrogenase 5,Trans-1,Trans-1,2-dihydrobenzene-1,2-diol dehydrogenase,Type IIb 3 alpha hydroxysteroid dehydrogenase
Host：Rabbit
Reactivity：Human,Mouse,Rat
Applications：WB,IHC
Concentration：1mg/ml
Immunogen：Recombinant protein of human AKR1C3
Purification Method：Affinity purification
Clonality：Polyclonal
Conjugation：Unconjugated
Dilution：WB 1：500 - 1：2000 IHC 1：50 - 1：200
Gene_ID（human）：8644
Swissprot：P42330
Isotype：IgG
Research Areas：Cancer, Metabolism, Neuroscience, Signal transduction
