Background：This gene encodes a member of the tumor necrosis factor （TNF） cytokine family which is a ligand for osteoprotegerin and functions as a key factor for osteoclast differentiation and activation. This protein was shown to be a dentritic cell survival factor and is involved in the regulation of T cell-dependent immune response. T cell activation was reported to induce expression of this gene and lead to an increase of osteoclastogenesis and bone loss. This protein was shown to activate antiapoptotic kinase AKT/PKB through a signaling complex involving SRC kinase and tumor necrosis factor receptor-associated factor （TRAF） 6, which indicated this protein may have a role in the regulation of cell apoptosis. Targeted disruption of the related gene in mice led to severe osteopetrosis and a lack of osteoclasts. The deficient mice exhibited defects in early differentiation of T and B lymphocytes, and failed to form lobulo-alveolar mammary structures during pregnancy. Two alternatively spliced transcript variants have been found.
仕様
Synonyms：CD254,hRANKL2,ODF,OPGL,OPTB2,Osteoclast differentiation factor,Osteoprotegerin ligand,RANKL,Receptor activator of nuclear factor kappa B ligand,Receptor activator of nuclear factor kappa-B ligand,sOdf,TNF related activation induced cytokine,TNF-related activation-induced cytokine,TNF11,TNFSF 11,Tnfsf11,TRANCE,Tumor necrosis factor （ligand） superfamily member 11,Tumor necrosis factor ligand superfamily member 11,Tumor necrosis factor ligand superfamily member 11,soluble form
Host：Rabbit
Reactivity：Human,Mouse,Rat
Applications：IHC,IF
Concentration：1mg/ml
Immunogen：Recombinant protein of human TNFSF11
Purification Method：Affinity purification
Clonality：Polyclonal
Conjugation：Unconjugated
Buffer：Buffer： PBS with 0.02％ sodium azide, 50％ glycerol, pH7.3.
