Background：The protein encoded by this gene is an epithelial-derived, integral membrane serine protease. This protease forms a complex with the Kunitz-type serine protease inhibitor, HAI-1, and is found to be activated by sphingosine 1-phosphate. This protease has been shown to cleave and activate hepatocyte growth factor/scattering factor, and urokinase plasminogen activator, which suggest the function of this protease as an epithelial membrane activator for other proteases and latent growth factors. The expression of this protease has been associated with breast, colon, prostate, and ovarian tumors, which implicates its role in cancer invasion, and metastasis.
仕様
Synonyms：Epithin,HAI,Matriptase,Membrane type serine protease 1,Membrane type serine protease,Membrane-type serine protease 1,MT SP1,MT-SP1,MTSP 1,MTSP1,Prostamin,PRSS 14,PRSS14,Serine protease 14,Serine protease TADG 15,Serine protease TADG-15,Serine protease TADG15,SNC 19,SNC19,ST 14,ST14,ST14,Suppression of tumorigenicity 14 （colon carcinoma matriptase epithin）,Suppression of tumorigenicity 14 （colon carcinoma）,Suppression of tumorigenicity 14,Suppressor of tumorigenicity 14 protein,Suppressor of tumorigenicity protein 14,TADG 15,TADG15,TMPRSS14,Tumor associated differentially expressed gene 15 protein,Tumor-associated differentially-expressed gene 15 protein
Host：Rabbit
Reactivity：Human,Mouse
Applications：WB,IHC
Concentration：1mg/ml
Immunogen：Recombinant protein of human ST14
Purification Method：Affinity purification
Clonality：Polyclonal
Conjugation：Unconjugated
Buffer：Buffer： PBS with 0.02％ sodium azide, 50％ glycerol, pH7.3.
Dilution：WB 1：500 - 1：2000 IHC 1：50 - 1：200
Gene_ID（human）：6768
Swissprot：Q9Y5Y6
Isotype：IgG
Research Areas：Cancer, Cell Biology, Signal transduction
