Background：The protein encoded by this gene is a receptor for interleukin 7 （IL7）. The function of this receptor requires the interleukin 2 receptor, gamma chain （IL2RG）, which is a common gamma chain shared by the receptors of various cytokines, including interleukins 2, 4, 7, 9, and 15. This protein has been shown to play a critical role in V（D）J recombination during lymphocyte development. Defects in this gene may be associated with severe combined immunodeficiency （SCID）. Alternatively spliced transcript variants have been found.
