Background：This gene encodes a ring finger protein that is major component of the polycomb group complex 1 （PRC1）. This complex functions through chromatin remodeling as an essential epigenetic repressor of multiple regulatory genes involved in embryonic development and self-renewal in somatic stem cells. This protein also plays a central role in DNA damage repair. This gene is an oncogene and aberrant expression is associated with numerous cancers and is associated with resistance to certain chemotherapies. A pseudogene of this gene is found on chromosome X. Read-through transcription also exists between this gene and the upstream COMM domain containing 3 （COMMD3） gene.
仕様
Synonyms：B lymphoma Mo MLV insertion region （mouse）,B lymphoma Mo MLV insertion region 1 homolog,Bmi 1,BMI1,BMI1 polycomb ring finger oncogene,BMI1,Flvi 2/bmi 1,FLVI2/BMI1,MGC12685,Murine leukemia viral （bmi 1） oncogene homolog,Oncogene BMI 1,PCGF 4,PCGF4,Polycomb complex protein BMI 1,Polycomb complex protein BMI-1,Polycomb group protein Bmi1,Polycomb group ring finger 4,Polycomb group RING finger protein 4,RING finger protein 51,RNF 51,RNF51
Host：Rabbit
Reactivity：Human,Mouse
Applications：WB,IF
Concentration：1mg/ml
Immunogen：Recombinant protein of human BMI1
Purification Method：Affinity purification
Clonality：Polyclonal
Conjugation：Unconjugated
Dilution：WB1：500 - 1：2000 IF1：50 - 1：200
Gene_ID（human）：100532731
Swissprot：P35226
Isotype：IgG
Research Areas：Cancer, Cell Biology, Epigenetics and Nuclear Signaling, Stem cells
