Background：This gene product is the main apolipoprotein of chylomicrons and low density lipoproteins. It occurs in plasma as two main isoforms, apoB-48 and apoB-100： the former is synthesized exclusively in the gut and the latter in the liver. The intestinal and the hepatic forms of apoB are encoded by a single gene from a single, very long mRNA. The two isoforms share a common N-terminal sequence. The shorter apoB-48 protein is produced after RNA editing of the apoB-100 transcript at residue 2180 （CAA-＞UAA）, resulting in the creation of a stop codon, and early translation termination. Mutations in this gene or its regulatory region cause hypobetalipoproteinemia, normotriglyceridemic hypobetalipoproteinemia, and hypercholesterolemia due to ligand-defective apoB, diseases affecting plasma cholesterol and apoB levels.
仕様
Synonyms：Apo B-100,Apo B-48,ApoB 100,ApoB 48,APOB,APOB,Apolipoprotein B （including Ag（x） antigen）,Apolipoprotein B 100,Apolipoprotein B,Apolipoprotein B-48,Apolipoprotein B48,FLDB,LDLCQ4
Host：Rabbit
Reactivity：Human,Mouse,Rat
Applications：WB
Concentration：1mg/ml
Immunogen：Recombinant protein of human APOB
Purification Method：Affinity purification
Clonality：Polyclonal
Conjugation：Unconjugated
Buffer：Buffer： PBS with 0.02％ sodium azide, 50％ glycerol, pH7.3.
Dilution：WB1：200 - 1：2000
Gene_ID（human）：338
Swissprot：P04114
Isotype：IgG
Research Areas：Cancer, Cardiovascular, Metabolism, Signal transduction
