Background：Complement component C3 plays a central role in the activation of complement system. Its activation is required for both classical and alternative complement activation pathways. The encoded preproprotein is proteolytically processed to generate alpha and beta subunits that form the mature protein, which is then further processed to generate numerous peptide products. The C3a peptide, also known as the C3a anaphylatoxin, modulates inflammation and possesses antimicrobial activity. Mutations in this gene are associated with atypical hemolytic uremic syndrome and age-related macular degeneration in human patients.
仕様
Synonyms：Acylation-stimulating protein cleavage product,AHUS5,ARMD9,ASP,C3 and PZP-like alpha-2-macroglobulin domain-containing protein 1,C3,CO3,Complement C3,Complement C3 beta chain,Complement C3c alpha' chain fragment 2,Complement component 3,Complement component C3,Complement factor 3,CPAMD1,Plp
Host：Rabbit
Reactivity：Human,Mouse,Rat
Applications：WB,IHC
Concentration：1mg/ml
Immunogen：Recombinant protein of human C3
Purification Method：Affinity purification
Clonality：Polyclonal
Conjugation：Unconjugated
Dilution：WB1：500 - 1：2000 IHC1：50 - 1：200
Gene_ID（human）：718
Swissprot：P01024
Isotype：IgG
Research Areas：Cancer, Immunology, Signal transduction
