Background：This gene encodes a kidney-specific sodium-potassium-chloride cotransporter that is expressed on the luminal membrane of renal epithelial cells of the thick ascending limb of Henle's loop and the macula densa. It plays a key role in concentrating urine and accounts for most of the NaCl resorption. It is sensitive to such diuretics as furosemide and bumetanide. Some Bartter-like syndromes result from defects in this gene. Alternative splicing results in multiple transcript variants encoding distinct isoforms. Additional splice variants have been described but their biological validity in humans has not been experimentally proven.
仕様
Synonyms：BSC1,Bumetanide sensitive sodium 3,Bumetanide-sensitive sodium-（potassium）-chloride cotransporter 2,Kidney specific Na K Cl symporter,Kidney-specific Na-K-Cl symporter,MGC48843,Na K 2Cl cotransporter,NKCC2,potassiumchloride cotransporter 2,S12A1,Slc12a1,sodium potassium chloride cotransporter 2,solute carrier family 12 （sodium/potassium/chloride transporters）,Solute carrier family 12 member 1
Host：Rabbit
Reactivity：Human,Mouse,Rat
Applications：WB
Concentration：1mg/ml
Immunogen：A synthetic peptide of human SLC12A1
Purification Method：Affinity purification
Clonality：Polyclonal
Conjugation：Unconjugated
Buffer：Buffer： PBS with 0.02％ sodium azide, 50％ glycerol, pH7.3.
Dilution：WB1：500 - 1：2000
Gene_ID（human）：6557
Swissprot：Q13621
Isotype：IgG
Research Areas：Cancer, Metabolism, Signal transduction
