Background：This gene encodes a member of the p53 family of transcription factors. The functional domains of p53 family proteins include an N-terminal transactivation domain, a central DNA-binding domain and an oligomerization domain. Alternative splicing of this gene and the use of alternative promoters results in multiple transcript variants encoding different isoforms that vary in their functional properties. These isoforms function during skin development and maintenance, adult stem/progenitor cell regulation, heart development and premature aging. Some isoforms have been found to protect the germline by eliminating oocytes or testicular germ cells that have suffered DNA damage. Mutations in this gene are associated with ectodermal dysplasia, and cleft lip/palate syndrome 3 （EEC3）; split-hand/foot malformation 4 （SHFM4）; ankyloblepharon-ectodermal defects-cleft lip/palate; ADULT syndrome （acro-dermato-ungual-lacrimal-tooth）; limb-mammary syndrome; Rap-Hodgkin syndrome （RHS）; and orofacial cleft 8.
仕様
Synonyms：AIS,Amplified in squamous cell carcinoma,B（p51A）,B（p51B）,Chronic ulcerative stomatitis protein,CUSP,DN p63 alpha 1,DNp63,EEC3,id：ibd3516,Keratinocyte transcription factor,Keratinocyte transcription factor KET,KET,LMS,MGC115972,MGC192897,NBP,OFC8,OTTHUMP00000209732,OTTHUMP00000209733,OTTHUMP00000209734,OTTHUMP00000209735,OTTHUMP00000209737,OTTHUMP00000209738,OTTHUMP00000209739,OTTHUMP00000209740,OTTHUMP00000209741,OTTHUMP00000209742,OTTHUMP00000209743,OTTHUMP00000209744,p40,p51,P51/P63,p53-related protein p63,p53CP,p63,P63,p73H,p73L,RHS,SHFM4,TAp63alpha,TP53CP,TP53L,TP63,TP73L,Transformation related protein 63,Transformation-related protein 63,Trp53rp1,Trp63,Tumor protein 63,Tumor protein p53-competing protein,Tumor protein p53-like,Tumor protein p63,Tumor protein p63 deltaN isoform delta,Tumor protein p73,Tumor protein p73-like
Host：Rabbit
Reactivity：Human,Mouse,Rat
Applications：WB
Concentration：1mg/ml
Immunogen：Recombinant protein of human TP63
Purification Method：Affinity purification
Clonality：Polyclonal
Conjugation：Unconjugated
Dilution：WB1：1000 - 1：2000
Gene_ID（human）：8626
Swissprot：Q9H3D4
Isotype：IgG
Research Areas：Cancer, Cell Biology, Epigenetics and Nuclear Signaling
