Background：The protein encoded by this gene belongs to the lin-28 family, which is characterized by the presence of a cold-shock domain and a pair of CCHC zinc finger domains. This gene is highly expressed in testis, fetal liver, placenta, and in primary human tumors and cancer cell lines. It is negatively regulated by microRNAs that target sites in the 3' UTR, and overexpression of this gene in primary tumors is linked to the repression of let-7 family of microRNAs and derepression of let-7 targets, which facilitates cellular transformation.
仕様
Synonyms：CSDD 2,CSDD2,FLJ16517,Lin 28 homolog B （C. elegans）,Lin 28.2,Lin-28B,LIN28B,LN28B,Protein lin-28 homolog B
Host：Rabbit
Reactivity：Human,Mouse
Applications：WB
Concentration：1mg/ml
Immunogen：Recombinant protein of human LIN28B
Purification Method：Affinity purification
Clonality：Polyclonal
Conjugation：Unconjugated
Buffer：Buffer： PBS with 0.02％ sodium azide, 50％ glycerol, pH7.3.
Dilution：WB 1：500 - 1：2000
Gene_ID（human）：389421
Swissprot：Q6ZN17
Isotype：IgG
Research Areas：Cancer, Epigenetics and Nuclear Signaling
