Background：The protein encoded by this gene is a member of the tripartite motif （TRIM） family. The TRIM motif includes three zinc-binding domains, a RING, a B-box type 1 and a B-box type 2, and a coiled-coil region. The protein localizes to the cytoplasm. The presence of potential DNA-binding and dimerization-transactivation domains suggests that this protein may act as a transcription factor, similar to several other members of the TRIM family. Expression of the gene is upregulated in response to estrogen, and it is thought to mediate estrogen actions in breast cancer as a primary response gene.
仕様
Synonyms：E3 ubiquitin/ISG15 ligase TRIM25,EFP,Estrogen responsive finger protein,Estrogen-responsive finger protein,RING finger protein 147,RNF 147,RNF147,TRI25,TRI25,TRIM 25,Trim25,Tripartite motif containing 25,Tripartite motif containing protein 25,Tripartite motif protein TRIM25,Tripartite motif-containing protein 25,Tripartite motifcontaining25,Ubiquitin/ISG15-conjugating enzyme TRIM25,Z147,Zinc finger protein 147 （estrogen responsive finger protein）,Zinc finger protein 147,Zinc finger protein-147,ZNF 147,ZNF147
Host：Rabbit
Reactivity：Human,Mouse
Applications：WB
Concentration：1mg/ml
Immunogen：Recombinant protein of human TRIM25
Purification Method：Affinity purification
Clonality：Polyclonal
Conjugation：Unconjugated
Buffer：Buffer： PBS with 0.02％ sodium azide, 50％ glycerol, pH7.3.
Dilution：WB1：500 - 1：2000
Gene_ID（human）：7706
Swissprot：Q14258
Isotype：IgG
Research Areas：Cancer, Cell Biology, Epigenetics and Nuclear Signaling, Signal transduction
