Background：This gene functions in two distinct complexes. It plays an active role in telomerase stabilization and maintenance, as well as recognition of snoRNAs containing H/ACA sequences which provides stability during biogenesis and assembly into H/ACA small nucleolar RNA ribonucleoproteins （snoRNPs）. This gene is highly conserved and widely expressed, and may play additional roles in nucleo-cytoplasmic shuttling, DNA damage response, and cell adhesion. Mutations have been associated with X-linked dyskeratosis congenita. Alternative splicing results in multiple transcript variants.
仕様
Synonyms：CBF5,CBF5 homolog,Cbf5p homolog,DKC 1,DKC,Dkc1,DKC1,DKCX,Dyskeratosis congenita 1,Dyskeratosis congenita 1 dyskerin,Dyskerin,H/ACA ribonucleoprotein complex subunit 4,NAP 57,NAP57,NOLA 4,NOLA4,Nopp140 associated protein of 57 kDa,Nopp140-associated protein of 57 kDa,Nucleolar protein family A member 4,Nucleolar protein NAP57,snoRNP protein DKC1,XAP 101,XAP101
Host：Rabbit
Reactivity：Human,Mouse
Applications：WB
Concentration：1mg/ml
Immunogen：Recombinant protein of human DKC1
Purification Method：Affinity purification
Clonality：Polyclonal
Conjugation：Unconjugated
Buffer：Buffer： PBS with 0.02％ sodium azide, 50％ glycerol, pH7.3.
Dilution：WB1：500 - 1：2000
Gene_ID（human）：1736
Swissprot：O60832
Isotype：IgG
Research Areas：Cancer, Epigenetics and Nuclear Signaling
