Background：This gene encodes a transcriptional regulator with bimodal DNA-binding specificity, which binds to methylated CGCG and also to the non-methylated consensus KAISO-binding site TCCTGCNA. The protein contains an N-terminal POZ/BTB domain and 3 C-terminal zinc finger motifs. It recruits the N-CoR repressor complex to promote histone deacetylation and the formation of repressive chromatin structures in target gene promoters. It may contribute to the repression of target genes of the Wnt signaling pathway, and may also activate transcription of a subset of target genes by the recruitment of catenin delta-2 （CTNND2）. Its interaction with catenin delta-1 （CTNND1） inhibits binding to both methylated and non-methylated DNA. It also interacts directly with the nuclear import receptor Importin-alpha2 （also known as karyopherin alpha2 or RAG cohort 1）, which may mediate nuclear import of this protein. Alternatively spliced transcript variants encoding the same protein have been identified.
仕様
Synonyms：Kaiso,Kaiso protein,Kaiso transcription factor,KAISO,Transcriptional regulator Kaiso,ZBTB 33,Zbtb33,Zinc finger and BTB domain containing 33,Zinc finger and BTB domain-containing protein 33,Zinc finger transcription factor Kaiso,ZNF 348,ZNF Kaiso,ZNF348
Host：Rabbit
Reactivity：Human,Mouse
Applications：WB
Concentration：1mg/ml
Immunogen：Recombinant protein of human ZBTB33
Purification Method：Affinity purification
Clonality：Polyclonal
Conjugation：Unconjugated
Buffer：Buffer： PBS with 0.02％ sodium azide, 50％ glycerol, pH7.3.
Dilution：WB1：1000 - 1：3000
Gene_ID（human）：10009
Swissprot：Q86T24
Isotype：IgG
Research Areas：Cancer, Epigenetics and Nuclear Signaling
