Background：The protein encoded by this gene belongs to the TDG/mug DNA glycosylase family. Thymine-DNA glycosylase （TDG） removes thymine moieties from G/T mismatches by hydrolyzing the carbon-nitrogen bond between the sugar-phosphate backbone of DNA and the mispaired thymine. With lower activity, this enzyme also removes thymine from C/T and T/T mispairings. TDG can also remove uracil and 5-bromouracil from mispairings with guanine. This enzyme plays a central role in cellular defense against genetic mutation caused by the spontaneous deamination of 5-methylcytosine and cytosine. This gene may have a pseudogene in the p arm of chromosome 12.
仕様
Synonyms：C JUN leucine zipper interactive protein ,C JUN leucine zipper interactive protein,C-JUN leucine zipper interactive protein JZA-3,E130317C12Rik,EC 3.2.2.29,G/T mismatch specific thymine DNA glycosylase ,G/T mismatch specific thymine DNA glycosylase,G/T mismatch-specific thymine DNA glycosylase,JZA 3,Jza1,T：G mismatch thymine glycosylase,Tdg,TDG,Thymine DNA glycosylase,Thymine-DNA glycosylase
Host：Rabbit
Reactivity：Mouse,Rat
Applications：WB
Concentration：1mg/ml
Immunogen：Recombinant protein of human TDG
Purification Method：Affinity purification
Clonality：Polyclonal
Conjugation：Unconjugated
Buffer：Buffer： PBS with 0.02％ sodium azide, 50％ glycerol, pH7.3.
Dilution：WB1：500 - 1：2000
Gene_ID（human）：6996
Swissprot：Q13569
Isotype：IgG
Research Areas：Cancer, Epigenetics and Nuclear Signaling
