Background：This gene encodes a member of a family of ubiquitously expressed heterogeneous nuclear ribonucleoproteins （hnRNPs）, which are RNA-binding proteins that associate with pre-mRNAs in the nucleus and influence pre-mRNA processing, as well as other aspects of mRNA metabolism and transport. The protein encoded by this gene is one of the most abundant core proteins of hnRNP complexes and plays a key role in the regulation of alternative splicing. Mutations in this gene have been observed in individuals with amyotrophic lateral sclerosis 20. Multiple alternatively spliced transcript variants have been found. There are numerous pseudogenes of this gene distributed throughout the genome.
仕様
Synonyms：HNRNPA 1,Helix destabilizing protein,Helix-destabilizing protein,Heterogeneous nuclear ribonucleoprotein A1,Heterogeneous nuclear ribonucleoprotein A1B protein,Heterogeneous nuclear ribonucleoprotein B2 protein,Heterogeneous nuclear ribonucleoprotein core protein A1,hnRNP A1,hnRNP core protein A1,HNRNPA1,HNRPA1,MGC102835,Nuclear ribonucleoprotein particle A1 protein,ROA1,Single strand DNA binding protein UP1,Single strand RNA binding protein,Single-strand RNA-binding protein
Host：Rabbit
Reactivity：Human,Mouse,Rat
Applications：WB,IF
Concentration：1mg/ml
Immunogen：Recombinant protein of human HNRNPA1
Purification Method：Affinity purification
Clonality：Polyclonal
Conjugation：Unconjugated
Buffer：Buffer： PBS with 0.02％ sodium azide, 50％ glycerol, pH7.3.
Dilution：WB1：500 - 1：2000 IF1：50 - 1：100
Gene_ID（human）：3178
Swissprot：P09651
Isotype：IgG
Research Areas：Cancer, Epigenetics and Nuclear Signaling
