Background：This gene encodes a ribosome-binding protein of the endoplasmic reticulum （ER） membrane. Studies suggest that this gene plays a role in ER proliferation, secretory pathways and secretory cell differentiation, and mediation of ER-microtubule interactions. Alternative splicing has been observed and protein isoforms are characterized by regions of N-terminal decapeptide and C-terminal heptad repeats. Splicing of the tandem repeats results in variations in ribosome-binding affinity and secretory function. The full-length nature of variants which differ in repeat length has not been determined. Pseudogenes of this gene have been identified on chromosomes 3 and 7, and RRBP1 has been excluded as a candidate gene in the cause of Alagille syndrome, the result of a mutation in a nearby gene on chromosome 20p12.
仕様
Synonyms：180 kDa ribosome receptor homolog,DKFZp586A1420,ES/130,ES/130 related protein,ES/130-related protein,ES130,FLJ36146,hES,KIAA1398,MGC157720,MGC157721,Ribosome binding protein 1,Ribosome binding protein 1 homolog 180kDa,Ribosome binding protein 1 homolog,Ribosome receptor protein,Ribosome-binding protein 1,RRBP 1,Rrbp1,RRBP1,RRP
Host：Rabbit
Reactivity：Human,Mouse
Applications：WB
Concentration：1mg/ml
Immunogen：Recombinant protein of human RRBP1
Purification Method：Affinity purification
Clonality：Polyclonal
Conjugation：Unconjugated
Buffer：Buffer： PBS with 0.02％ sodium azide, 50％ glycerol, pH7.3.
Dilution：WB1：500 - 1：2000
Gene_ID（human）：6238
Swissprot：Q9P2E9
Isotype：IgG
Research Areas：Cancer, Epigenetics and Nuclear Signaling
