Background：Coenzyme A （CoA） functions as a carrier of acetyl and acyl groups in cells and thus plays an important role in numerous synthetic and degradative metabolic pathways in all organisms. In eukaryotes, CoA and its derivatives are also involved in membrane trafficking and signal transduction. This gene encodes the bifunctional protein coenzyme A synthase （CoAsy） which carries out the last two steps in the biosynthesis of CoA from pantothenic acid （vitamin B5）. The phosphopantetheine adenylyltransferase domain of this bifunctional protein catalyzes the conversion of 4'-phosphopantetheine into dephospho-coenzyme A （dpCoA） while its dephospho-CoA kinase domain completes the final step by phosphorylating dpCoA to form CoA. Mutations in this gene are associated with neurodegeneration with brain iron accumulation （NBIA）. Alternative splicing results in multiple isoforms.
仕様
Synonyms：Bifunctional coenzyme A synthase,Bifunctional phosphopantetheine adenylyl transferase/dephospho CoA kinase,CoA synthase,COASY,COASY,Coenzyme A synthase,Dephospho-CoA kinase,Dephospho-CoA pyrophosphorylase,Dephosphocoenzyme A kinase,DPCK,DPCOAK,NBP,Nucleotide binding protein,Pantetheine-phosphate adenylyltransferase,Phosphopantetheine adenylyltransferase / dephosphocoenzyme A kinase,pOV 2,POV-2,POV2,PPAT,UKR1
Host：Rabbit
Reactivity：Human,Mouse,Rat
Applications：WB
Concentration：1mg/ml
Immunogen：Recombinant protein of human COASY
Purification Method：Affinity purification
Clonality：Polyclonal
Conjugation：Unconjugated
Buffer：Buffer： PBS with 0.02％ sodium azide, 50％ glycerol, pH7.3.
Dilution：WB1：500 - 1：2000
Gene_ID（human）：80347
Swissprot：Q13057
Isotype：IgG
Research Areas：Cancer, Metabolism, Signal transduction
