Background：The protein encoded by this gene is a pyruvate kinase that catalyzes the transphosphorylation of phohsphoenolpyruvate into pyruvate and ATP, which is the rate-limiting step of glycolysis. Defects in this enzyme, due to gene mutations or genetic variations, are the common cause of chronic hereditary nonspherocytic hemolytic anemia （CNSHA or HNSHA）. Multiple transcript variants encoding different isoforms have been found for this gene.
仕様
Synonyms：EC 2.7.1.40,KPYR,L-PK,Pk-1,PK1 ,PKL ,Pklg,Pklr,PKR,PKRL,Pyruvate kinase 1,Pyruvate kinase isozymes R/L,Pyruvate kinase liver and blood cell,Pyruvate kinase liver and RBC,Pyruvate kinase liver and red blood cell,Pyruvate kinase liver type,Pyruvate kinase type L,Pyruvate kinase, red cell type,R type/L type pyruvate kinase,R-PK,R-type/L-type pyruvate kinase,Red cell/liver pyruvate kinase,RPK
Host：Rabbit
Reactivity：Human,Mouse,Rat
Applications：WB
Concentration：1mg/ml
Immunogen：Recombinant protein of human PKLR
Purification Method：Affinity purification
Clonality：Polyclonal
Conjugation：Unconjugated
Buffer：Buffer： PBS with 0.02％ sodium azide, 50％ glycerol, pH7.3.
Dilution：WB1：500 - 1：2000
Gene_ID（human）：5313
Swissprot：P30613
Isotype：IgG
Research Areas：Cancer, Metabolism, Signal transduction
