Background：DNA methylation is the major modification of eukaryotic genomes and plays an essential role in mammalian development. Human proteins MECP2, MBD1, MBD2, MBD3, and MBD4 comprise a family of nuclear proteins related by the presence in each of a methyl-CpG binding domain （MBD）. Each of these proteins, with the exception of MBD3, is capable of binding specifically to methylated DNA. MECP2, MBD1 and MBD2 can also repress transcription from methylated gene promoters. The protein encoded by this gene may function as a mediator of the biological consequences of the methylation signal. It is also reported that the this protein functions as a demethylase to activate transcription, as DNA methylation causes gene silencing. Two transcript variants encoding different isoforms have been found for this gene.
仕様
Synonyms：Demethylase,DMTase,MBD 2,Mbd2,MBD2,MBD2a,Methyl CpG binding domain protein 2,Methyl CpG binding protein MBD2,Methyl-CpG-binding domain protein 2,Methyl-CpG-binding protein MBD2,NY CO 41
Host：Rabbit
Reactivity：Mouse,Rat
Applications：WB
Concentration：1mg/ml
Immunogen：A synthetic peptide of human MBD2
Purification Method：Affinity purification
Clonality：Polyclonal
Conjugation：Unconjugated
Dilution：WB 1：500 - 1：2000
Gene_ID（human）：8932
Swissprot：Q9UBB5
Isotype：IgG
Research Areas：Cancer, Epigenetics and Nuclear Signaling
