Background：HIV-1, the causative agent of acquired immunodeficiency syndrome （AIDS）, contains an RNA genome that produces a chromosomally integrated DNA during the replicative cycle. Activation of HIV-1 gene expression by the transactivator Tat is dependent on an RNA regulatory element （TAR） located downstream of the transcription initiation site. The protein encoded by this gene is a transcriptional repressor that binds to chromosomally integrated TAR DNA and represses HIV-1 transcription. In addition, this protein regulates alternate splicing of the CFTR gene. A similar pseudogene is present on chromosome 20.
仕様
Synonyms：ALS10,OTTHUMP00000002171,OTTHUMP00000002172,OTTHUMP00000002173,TADBP,TAR DNA binding protein 43,TAR DNA binding protein,TAR DNA-binding protein 43,TARDBP,TDP 43,TDP-43,TDP43
Host：Rabbit
Reactivity：Human,Mouse,Rat
Applications：WB,IHC,IF,IP
Concentration：1mg/ml
Immunogen：Recombinant protein of human TARDBP
Purification Method：Affinity purification
Clonality：Polyclonal
Conjugation：Unconjugated
Buffer：Buffer： PBS with 0.02％ sodium azide, 50％ glycerol, pH7.3.
Dilution：WB 1：500 - 1：2000 IHC 1：50 - 1：100 IF 1：20 - 1：100 IP 1：50 - 1：100
Gene_ID（human）：23435
Swissprot：Q13148
Isotype：IgG
Research Areas：Cancer, Epigenetics and Nuclear Signaling, Microbiology, Neuroscience
