Background：This gene encodes an adaptor protein that is composed of two protein-protein interaction domains： a N-terminal PYRIN-PAAD-DAPIN domain （PYD） and a C-terminal caspase-recruitment domain （CARD）. The PYD and CARD domains are members of the six-helix bundle death domain-fold superfamily that mediates assembly of large signaling complexes in the inflammatory and apoptotic signaling pathways via the activation of caspase. In normal cells, this protein is localized to the cytoplasm; however, in cells undergoing apoptosis, it forms ball-like aggregates near the nuclear periphery. Two transcript variants encoding different isoforms have been found for this gene.
仕様
Synonyms：Apoptosis associated speck like protein containing a CARD,Apoptosis-associated speck-like protein containing a CARD,ASC,ASC,CARD 5,CARD5,Caspase recruitment domain containing protein 5,Caspase recruitment domain protein 5,Caspase recruitment domain-containing protein 5,hASC,MGC10332,PYCARD,PYD and CARD domain containing,PYD and CARD domain containing protein,PYD and CARD domain-containing protein,Target of methylation induced silencing 1,Target of methylation-induced silencing 1,TMS 1,TMS,TMS1
Host：Rabbit
Reactivity：Human,Mouse,Rat
Applications：WB,IHC,IF
Concentration：1mg/ml
Immunogen：Recombinant protein of human PYCARD
Purification Method：Affinity purification
Clonality：Polyclonal
Conjugation：Unconjugated
Buffer：Buffer： PBS with 0.02％ sodium azide, 50％ glycerol, pH7.3.
