Background：This gene encodes a secreted ligand of the TGF-beta （transforming growth factor-beta） superfamily of proteins. Ligands of this family bind various TGF-beta receptors leading to recruitment and activation of SMAD family transcription factors that regulate gene expression. The encoded preproprotein is proteolytically processed to generate each subunit of the disulfide-linked homodimer. This protein regulates heart development and adipogenesis. Mutations in this gene are associated with orofacial cleft and microphthalmia in human patients. The encoded protein may also be involved in the pathology of multiple cardiovascular diseases and human cancers.
仕様
Synonyms：zgc：100779,BMP 2B,BMP 4,BMP-2B,BMP-4,BMP2B,BMP2B1,BMP4,BMP4,Bone morphogenetic protein 2B,Bone morphogenetic protein 4,DVR4,MCOPS6,MGC100779,OFC11,zbmp-4,ZYME
Host：Rabbit
Reactivity：Human,Mouse,Rat
Applications：IHC
Concentration：1mg/ml
Immunogen：Recombinant protein of human BMP4
Purification Method：Affinity purification
Clonality：Polyclonal
Conjugation：Unconjugated
Buffer：Buffer： PBS with 0.02％ sodium azide, 50％ glycerol, pH7.3.
Dilution：IHC1：50 - 1：100
Gene_ID（human）：652
Swissprot：P12644
Isotype：IgG
Research Areas：Cancer, Cardiovascular, Developmental biology, Signal transduction, Stem cells
