Background：This gene encodes a multifunctional protein that binds ubiquitin and regulates activation of the nuclear factor kappa-B （NF-kB） signaling pathway. The protein functions as a scaffolding/adaptor protein in concert with TNF receptor-associated factor 6 to mediate activation of NF-kB in response to upstream signals. Alternatively spliced transcript variants encoding either the same or different isoforms have been identified for this gene. Mutations in this gene result in sporadic and familial Paget disease of bone.
仕様
Synonyms：A170,DMRV,EBI 3 associated protein of 60 kDa,EBI 3 associated protein p60,EBI3 associated protein of 60 kDa,EBI3 associated protein p60,EBI3-associated protein of 60 kDa,EBIAP,FTDALS3,MGC127197,ORCA,OSF-6,Osi,OSIL,Oxidative stress induced like,p60,p62,p62B,Paget disease of bone 3,PDB 3,PDB3,Phosphotyrosine independent ligand for the Lck SH2 domain of 62 kDa,Phosphotyrosine independent ligand for the Lck SH2 domain p62,Phosphotyrosine-independent ligand for the Lck SH2 domain of 62 kDa,PKC-zeta-interacting protein,Protein kinase C-zeta-interacting protein,Sequestosome 1,Sequestosome-1,SQSTM 1,SQSTM,Sqstm1,STAP,STONE14,Ubiquitin binding protein p62,Ubiquitin-binding protein p62,ZIP 3,ZIP,ZIP3
Host：Rabbit
Reactivity：Human,Mouse,Rat
Applications：WB,IHC
Concentration：1mg/ml
Immunogen：Recombinant protein of human SQSTM1
Purification Method：Affinity purification
Clonality：Polyclonal
Conjugation：Unconjugated
Buffer：Buffer： PBS with 0.02％ sodium azide, 50％ glycerol, pH7.3.
Dilution：WB 1：500 - 1：2000 IHC 1：50 - 1：200
Gene_ID（human）：8878
Swissprot：Q13501
Isotype：IgG
Research Areas：Cancer, Cardiovascular, Epigenetics and Nuclear Signaling, Metabolism, Signal transduction
