Background：This gene encodes a protein containing a death domain （DD） motif. This protein recruits caspase 2/ICH1 to the cell death signal transduction complex, which includes tumor necrosis factor receptor 1 （TNFR1A） and RIPK1/RIP kinase, and acts in promoting apoptosis. A mutation in this gene was associated with mental retardation. A related pseudogene is found on chromosome 3. Alternative splicing results in multiple transcript variants.
仕様
Synonyms：CASP2 and RIPK1 domain containing adaptor with death domain,Caspase and RIP adapter with death domain,Caspase and RIP adaptor with death domain,Cradd,CRADD,Death adaptor molecule RAIDD,Death domain containing protein CRADD,Death domain-containing protein CRADD,MGC9163,RIP associated ICH1/CED3 homologous protein with death domain,RIP associated protein with a death domain,RIP-associated protein with a death domain
Host：Rabbit
Reactivity：Human,Mouse,Rat
Applications：WB
Concentration：1mg/ml
Immunogen：Recombinant protein of human CRADD
Purification Method：Affinity purification
Clonality：Polyclonal
Conjugation：Unconjugated
Buffer：Buffer： PBS with 0.02％ sodium azide, 50％ glycerol, pH7.3.
