Background：The protein encoded by this gene is a member of the Toll-like receptor （TLR） family which plays a fundamental role in pathogen recognition and activation of innate immunity. TLRs are highly conserved from Drosophila to humans and share structural and functional similarities. This protein is a cell-surface protein that can form heterodimers with other TLR family members to recognize conserved molecules derived from microorganisms known as pathogen-associated molecular patterns （PAMPs）. Activation of TLRs by PAMPs leads to an up-regulation of signaling pathways to modulate the host's inflammatory response. This gene is also thought to promote apoptosis in response to bacterial lipoproteins. This gene has been implicated in the pathogenesis of several autoimmune diseases. Alternative splicing results in multiple transcript variants.
仕様
Synonyms：CD282,CD282 antigen,TIL 4,TIL4,TLR 2,TLR2,TLR2,Toll like receptor 2,Toll like receptor 2 precursor,Toll-like receptor 2,Toll/interleukin 1 receptor like 4,Toll/interleukin 1 receptor like protein 4,Toll/interleukin receptor like protein 4,Toll/interleukin-1 receptor-like protein 4
Host：Rabbit
Reactivity：Human,Mouse,Rat
Applications：WB,IHC
Concentration：1mg/ml
Immunogen：A synthetic peptide of human TLR2
Purification Method：Affinity purification
Clonality：Polyclonal
Conjugation：Unconjugated
Buffer：Buffer： PBS with 0.02％ sodium azide, 50％ glycerol, pH7.3.
Dilution：WB1：200 - 1：500 IHC1：50 - 1：100
Gene_ID（human）：7097
Swissprot：O60603
Isotype：IgG
Research Areas：Cancer, Cardiovascular, Immunology, Microbiology, Signal transduction
