Background：This gene encodes a member of the MAP kinase family. MAP kinases, also known as extracellular signal-regulated kinases （ERKs）, act as an integration point for multiple biochemical signals, and are involved in a wide variety of cellular processes such as proliferation, differentiation, transcription regulation and development. The activation of this kinase requires its phosphorylation by upstream kinases. Upon activation, this kinase translocates to the nucleus of the stimulated cells, where it phosphorylates nuclear targets. One study also suggests that this protein acts as a transcriptional repressor independent of its kinase activity. The encoded protein has been identified as a moonlighting protein based on its ability to perform mechanistically distinct functions. Two alternatively spliced transcript variants encoding the same protein, but differing in the UTRs, have been reported for this gene.
仕様
Synonyms：ERK 2,ERK,ERK-2,ERT1,Extracellular Signal Regulated Kinase 2,Extracellular signal-regulated kinase 2,MAP kinase 1,MAP kinase 2,MAP kinase isoform p42,MAPK 1,MAPK 2,Mapk1,MAPK2,Mitogen-activated protein kinase 1,Mitogen-activated protein kinase 2,MK01,P38,P40,P41,p42-MAPK,P42MAPK,PRKM1,PRKM2,protein kinase,mitogen-activated,1,protein kinase,mitogen-activated,2,protein tyrosine kinase ERK2
Host：Rabbit
Reactivity：Human,Mouse,Rat
Applications：WB,IHC
Concentration：1mg/ml
Immunogen：A synthetic peptide of human MAPK1
Purification Method：Affinity purification
Clonality：Polyclonal
Conjugation：Unconjugated
Buffer：Buffer： PBS with 0.02％ sodium azide, 50％ glycerol, pH7.3.
Dilution：WB1：500 - 1：2000 IHC1：50 - 1：100
Gene_ID（human）：5594
Swissprot：P28482
Isotype：IgG
Research Areas：Cancer, Neuroscience, Signal transduction, Stem cells
