Background：The precise function of this gene is unknown; however, the encoded protein is a component of a multiprotein E3 ubiquitin ligase complex that mediates the targeting of substrate proteins for proteasomal degradation. Mutations in this gene are known to cause Parkinson disease and autosomal recessive juvenile Parkinson disease. Alternative splicing of this gene produces multiple transcript variants encoding distinct isoforms. Additional splice variants of this gene have been described but currently lack transcript support.
仕様
Synonyms：AR JP,E3 ubiquitin ligase,E3 ubiquitin protein ligase parkin,E3 ubiquitin-protein ligase parkin,FRA6E,LPRS 2,LPRS2,PARK 2,Park2,Parkin 2,Parkinson disease （autosomal recessive juvenile） 2,Parkinson disease （autosomal recessive,juvenile） 2,parkin,Parkinson disease protein 2,Parkinson juvenile disease protein 2,Parkinson protein 2 E3 ubiquitin protein ligase,Parkinson protein 2,E3 ubiquitin protein ligase （parkin）,PDJ,PRKN 2,PRKN,PRKN2,PRKN2,Ubiquitin E3 ligase PRKN
Host：Rabbit
Reactivity：Human,Mouse
Applications：WB,IF
Concentration：1mg/ml
Immunogen：Recombinant protein of human PARK2
Purification Method：Affinity purification
Clonality：Polyclonal
Conjugation：Unconjugated
Buffer：Buffer： PBS with 0.02％ sodium azide, 50％ glycerol, pH7.3.
Dilution：WB1：500 - 1：2000 IF1：50 - 1：200
Gene_ID（human）：5071
Swissprot：O60260
Isotype：IgG
Research Areas：Cancer, Cell Biology, Metabolism, Neuroscience
