Background:This gene encodes a member of the myotubularin dual specificity protein phosphatase gene family. The encoded protein is structurally similar to myotubularin but in addition contains a FYVE domain and an N-terminal PH-GRAM domain. The protein can self-associate and also form heteromers with another myotubularin related protein. The protein binds to phosphoinositide lipids through the PH-GRAM domain, and can hydrolyze phosphatidylinositol(3)-phosphate and phosphatidylinositol(3,5)-biphosphate in vitro. The encoded protein has been observed to have a perinuclear, possibly membrane-bound, distribution in cells, but it has also been found free in the cytoplasm. Multiple transcript variants encoding different isoforms have been found for this gene.
仕様
Synonyms:FYVE domain-containing dual specificity protein phosphatase 1,FYVE-DSP1,MTMR3,MTMR3,Myotubularin-related protein 3,Zinc finger FYVE domain-containing protein 10
Host:Rabbit
Reactivity:Human
Applications:WB
Concentration:1mg/ml
Immunogen:Recombinant protein of human MTMR3
Purification Method:Affinity purification
Clonality:Polyclonal
Conjugation:Unconjugated
Buffer:Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.