Background：The protein encoded by this gene is an isozyme of long-chain fatty-acid-coenzyme A ligase family. Although differing in substrate specificity, subcellular localization, and tissue distribution, all isozymes of this family convert free long-chain fatty acids into fatty acyl-CoA esters, and thereby play a key role in lipid biosynthesis and fatty acid degradation. This isozyme activates long-chain, branched-chain and very-long-chain fatty acids containing 22 or more carbons to their CoA derivatives. It is expressed primarily in liver and kidney, and is present in both endoplasmic reticulum and peroxisomes, but not in mitochondria. Its decreased peroxisomal enzyme activity is in part responsible for the biochemical pathology in X-linked adrenoleukodystrophy. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.
仕様
Synonyms：ACSVL1,FACVL1,FATP 2,FATP-2,FATP2,Fatty acid coenzyme A ligase,very long chain 1,Fatty acid transport protein 2,Fatty-acid-coenzyme A ligase,hFACVL1,HsT17226,Long chain fatty acid CoA ligase,Long-chain-fatty-acid--CoA ligase,S27A2,Slc27a2,Solute carrier family 27 （fatty acid transporter）,member 2,Solute carrier family 27 member 2,THCA CoA ligase,THCA-CoA ligase,Very long chain acyl CoA synthetase,Very long chain fatty acid CoA ligase,Very long chain fatty acid coenzyme A ligase 1,very long-chain 1,Very long-chain acyl-CoA synthetase,Very long-chain-fatty-acid-CoA ligase,VLACS,VLCS
Host：Rabbit
Reactivity：Human,Mouse
Applications：WB
Concentration：1mg/ml
Immunogen：Recombinant protein of human SLC27A2
Purification Method：Affinity purification
Clonality：Polyclonal
Conjugation：Unconjugated
Buffer：Buffer： PBS with 0.02％ sodium azide, 50％ glycerol, pH7.3.
Dilution：WB 1：500 - 1：2000
Gene_ID（human）：11001
Swissprot：O14975
Isotype：IgG
Research Areas：Cancer, Cardiovascular, Metabolism, Signal transduction
