Background：This intronless gene is thought to have been generated by retrotransposition of a fully processed PCBP-2 mRNA. This gene and PCBP-2 have paralogues （PCBP3 and PCBP4） which are thought to have arisen as a result of duplication events of entire genes. The protein encoded by this gene appears to be multifunctional. It along with PCBP-2 and hnRNPK corresponds to the major cellular poly（rC）-binding protein. It contains three K-homologous （KH） domains which may be involved in RNA binding. This encoded protein together with PCBP-2 also functions as translational coactivators of poliovirus RNA via a sequence-specific interaction with stem-loop IV of the IRES and promote poliovirus RNA replication by binding to its 5'-terminal cloverleaf structure. It has also been implicated in translational control of the 15-lipoxygenase mRNA, human Papillomavirus type 16 L2 mRNA, and hepatitis A virus RNA. The encoded protein is also suggested to play a part in formation of a sequence-specific alpha-globin mRNP complex which is associated with alpha-globin mRNA stability.
仕様
Synonyms：Alpha-CP1,Heterogeneous nuclear ribonucleoprotein E1,heterogenous nuclear ribonucleoprotein E1,heterogenous nuclear ribonucleoprotein X,hnRNP E1,hnRNP-E1 ,hnRNP-X ,HNRPE1,HNRPX,nucleic acid binding protein sub 2.3,Nucleic acid- binding protein SUB2.3,Nucleic acid-binding protein SUB2.3,PCBP1,PCBP1,poly（rC） binding protein 1,Poly（rC）-binding protein 1,rCbinding protein 1
Host：Rabbit
Reactivity：Human,Mouse,Rat
Applications：WB,IHC
Concentration：1mg/ml
Immunogen：A synthetic peptide of human PCBP1
Purification Method：Affinity purification
Clonality：Polyclonal
Conjugation：Unconjugated
Buffer：Buffer： PBS with 0.02％ sodium azide, 50％ glycerol, pH7.3.
Dilution：WB1：500 - 1：2000 IHC1：50 - 1：100
Gene_ID（human）：5093
Swissprot：Q15365
Isotype：IgG
Research Areas：Cancer, Epigenetics and Nuclear Signaling
