Background：The protein encoded by this gene contains a STE20-like kinase domain, but lacks several residues that are critical for catalytic activity, so it is termed a 'pseudokinase'. The protein forms a heterotrimeric complex with serine/threonine kinase 11 （STK11, also known as LKB1） and the scaffolding protein calcium binding protein 39 （CAB39, also known as MO25）. The protein activates STK11 leading to the phosphorylation of both proteins and excluding STK11 from the nucleus. The protein is necessary for STK11-induced G1 cell cycle arrest. A mutation in this gene has been shown to result in polyhydramnios, megalencephaly, and symptomatic epilepsy （PMSE） syndrome. Multiple transcript variants encoding different isoforms have been found for this gene. Additional transcript variants have been described but their full-length nature is not known.
仕様
Synonyms：Protein kinase LYK5,Serologically defined breast cancer antigen NY BR 96,STE20 related adapter protein,STRAD alpha,STRAD
Host：Rabbit
Reactivity：Human,Mouse
Applications：WB
Concentration：1mg/ml
Immunogen：Recombinant protein of human STRADA
Purification Method：Affinity purification
Clonality：Polyclonal
Conjugation：Unconjugated
Buffer：Buffer： PBS with 0.02％ sodium azide, 50％ glycerol, pH7.3.
Dilution：WB1：1000 - 1：2000
Gene_ID（human）：92335
Swissprot：Q7RTN6
Isotype：IgG
Research Areas：Cancer, Cell Biology, Metabolism, Immunology
