Background：The protein encoded by this gene functions as a transcriptional coactivator for nuclear hormone receptors, including steroid, thyroid, retinoid, and vitamin D receptors. The encoded protein acts as an intermediary factor for the ligand-dependent activity of these nuclear receptors, which regulate their target genes upon binding of cognate response elements. This gene has been found to be involved in translocations that result in fusions with other genes in various cancers, including the lysine acetyltransferase 6A （KAT6A） gene in acute myeloid leukemia, the ETS variant 6 （ETV6） gene in acute lymphoblastic leukemia, and the hes related family bHLH transcription factor with YRPW motif 1 （HEY1） gene in mesenchymal chondrosarcoma. Alternative splicing results in multiple transcript variants.
仕様
Synonyms：bHLHe75,Class E basic helix-loop-helix protein 75,glucocorticoid receptor interacting protein 1,GRIP 1,GRIP1,hTIF2,MED1,MGC138808,NCoA 2,NCoA-2,Ncoa2,NCOA2,Nuclear receptor coactivator 2,Oncogene FGR,p160,SRC 2,src2,Steroid receptor coactivator 2,TIF 2,TIF2,Transcriptional intermediary factor 2
Host：Rabbit
Reactivity：Human,Mouse,Rat
Applications：WB,IHC
Concentration：1mg/ml
Immunogen：Recombinant protein of human NCOA2
Purification Method：Affinity purification
Clonality：Polyclonal
Conjugation：Unconjugated
Buffer：Buffer： PBS with 0.02％ sodium azide, 50％ glycerol, pH7.3.
Dilution：WB1：500 - 1：2000 IHC1：50 - 1：200
Gene_ID（human）：10499
Swissprot：Q15596
Isotype：IgG
Research Areas：Cancer, Epigenetics and Nuclear Signaling, Metabolism
