Background：This gene encodes a member of the desmocollin protein subfamily. Desmocollins, along with desmogleins, are cadherin-like transmembrane glycoproteins that are major components of the desmosome. Desmosomes are cell-cell junctions that help resist shearing forces and are found in high concentrations in cells subject to mechanical stress. This gene is found in a cluster with other desmocollin family members on chromosome 18. Mutations in this gene are associated with arrhythmogenic right ventricular dysplasia-11, and reduced protein expression has been described in several types of cancer. Alternative splicing results in multiple transcript variants.
仕様
Synonyms：ARVD11,Cadherin family member 2,CDHF2,Desmocollin 3,Desmocollin-2,Desmocollin-3,Desmocollin2,Desmosomal glycoprotein II and III,Desmosomal glycoprotein II,Desmosomal glycoprotein II/III,Desmosomal glycoprotein III,DG2,DGII/III,DKFZp686I11137,DSC 2,DSC2,DSC2,DSC3
Host：Rabbit
Reactivity：Human
Applications：WB
Concentration：1mg/ml
Immunogen：Recombinant protein of human DSC2
Purification Method：Affinity purification
Clonality：Polyclonal
Conjugation：Unconjugated
Buffer：Buffer： PBS with 0.02％ sodium azide, 50％ glycerol, pH7.3.
Dilution：WB1：1000 - 1：2000
Gene_ID（human）：1824
Swissprot：Q02487
Isotype：IgG
Research Areas：Cardiovascular, Signal transduction
