Background：This gene encodes a member of the lysyl oxidase family of proteins. The prototypic member of the family is essential to the biogenesis of connective tissue, encoding an extracellular copper-dependent amine oxidase that catalyzes the first step in the formation of crosslinks in collagen and elastin. The encoded preproprotein is proteolytically processed to generate the mature enzyme. A highly conserved amino acid sequence at the C-terminus end appears to be sufficient for amine oxidase activity, suggesting that each family member may retain this function. The N-terminus is poorly conserved and may impart additional roles in developmental regulation, senescence, tumor suppression, cell growth control, and chemotaxis to each member of the family. Mutations in this gene are associated with exfoliation syndrome.
仕様
Synonyms：Lysyl oxidase like 1,LOL,LOXL,Lysyl oxidase homolog 1,Lysyl oxidase like protein 1
Host：Rabbit
Reactivity：Human,Mouse,Rat
Applications：WB
Concentration：1mg/ml
Immunogen：Recombinant protein of human LOXL1
Purification Method：Affinity purification
Clonality：Polyclonal
Conjugation：Unconjugated
Buffer：Buffer： PBS with 0.02％ sodium azide, 50％ glycerol, pH7.3.
Dilution：WB1：1000 - 1：3000
Gene_ID（human）：4016
Swissprot：Q08397
Isotype：IgG
Research Areas：Cell Biology, Metabolism, Signal transduction
