Background：This gene encodes the enzyme that metabolizes thiopurine drugs via S-adenosyl-L-methionine as the S-methyl donor and S-adenosyl-L-homocysteine as a byproduct. Thiopurine drugs such as 6-mercaptopurine are used as chemotherapeutic agents. Genetic polymorphisms that affect this enzymatic activity are correlated with variations in sensitivity and toxicity to such drugs within individuals, causing thiopurine S-methyltransferase deficiency. Related pseudogenes have been identified on chromosomes 3, 18 and X.
仕様
Synonyms：HGNC：12014,S adenosyl L methionine thiopurine S methyltransferase,Thiopurine methyltransferase,Thiopurine S methyltransferase,Thiopurine S-methyltransferase,TPMT,TPMT
Host：Rabbit
Reactivity：Human,Mouse
Applications：WB,IF
Concentration：1mg/ml
Immunogen：Recombinant protein of human TPMT
Purification Method：Affinity purification
Clonality：Polyclonal
Conjugation：Unconjugated
Dilution：WB1：500 - 1：2000 IF1：10 - 1：100
Gene_ID（human）：7172
Swissprot：P51580
Isotype：IgG
Research Areas：Cancer, Metabolism, Signal transduction
