Background：Voltage-gated sodium channels are heteromeric proteins that function in the generation and propagation of action potentials in muscle and neuronal cells. They are composed of one alpha and two beta subunits, where the alpha subunit provides channel activity and the beta-1 subunit modulates the kinetics of channel inactivation. This gene encodes a sodium channel beta-1 subunit. Mutations in this gene result in generalized epilepsy with febrile seizures plus, Brugada syndrome 5, and defects in cardiac conduction. Multiple transcript variants encoding different isoforms have been found for this gene.
仕様
Synonyms：GEFSP1,SCN1B,SCN1B,sodium channel beta 1 subunit,Sodium channel subunit beta 1,Sodium channel subunit beta-1,Sodium channel voltage gated type I beta,Sodium channel voltage gated type I beta subunit
Host：Rabbit
Reactivity：Human,Mouse,Rat
Applications：WB
Concentration：1mg/ml
Immunogen：Recombinant protein of human SCN1B
Purification Method：Affinity purification
Clonality：Polyclonal
Conjugation：Unconjugated
Buffer：Buffer： PBS with 0.02％ sodium azide, 50％ glycerol, pH7.3.
Dilution：WB1：500 - 1：2000
Gene_ID（human）：6324
Swissprot：Q07699
Isotype：IgG
Research Areas：Cancer, Metabolism, Neuroscience, Signal transduction
