Background：This intronless gene encodes a transcription factor that contains a basic leucine zipper （bZIP） domain and recognizes the CCAAT motif in the promoters of target genes. The encoded protein functions in homodimers and also heterodimers with CCAAT/enhancer-binding proteins beta and gamma. Activity of this protein can modulate the expression of genes involved in cell cycle regulation as well as in body weight homeostasis. Mutation of this gene is associated with acute myeloid leukemia. The use of alternative in-frame non-AUG （GUG） and AUG start codons results in protein isoforms with different lengths. Differential translation initiation is mediated by an out-of-frame, upstream open reading frame which is located between the GUG and the first AUG start codons.
仕様
Synonyms：Apoptotic cysteine protease,Apoptotic protease Mch 5,C/EBP alpha,C/ebpalpha,CAP4,Caspase 8 precursor,CBF-A,CCAAT Enhancer Binding Protein alpha,CCAAT/enhancer binding protein （C/EBP）,alpha,CCAAT/enhancer-binding protein alpha,CEBP,CEBP A,CEBP alpha,Cebpa,CEBPA,FADD homologous ICE/CED 3 like protease,FADD like ICE,FLICE,ICE like apoptotic protease 5,ICE8,MACH,MCH5,MORT1 associated CED 3 homolog
Host：Rabbit
Reactivity：Human,Mouse,Rat
Applications：WB,IHC
Concentration：1mg/ml
Immunogen：Recombinant protein of human CEBPA
Purification Method：Affinity purification
Clonality：Polyclonal
Conjugation：Unconjugated
Buffer：Buffer： PBS with 0.02％ sodium azide, 50％ glycerol, pH7.3.
Dilution：WB1：500 - 1：2000 IHC1：50 - 1：200
Gene_ID（human）：1050
Swissprot：P49715
Isotype：IgG
Research Areas：Cancer, Cardiovascular, Epigenetics and Nuclear Signaling, Metabolism, Signal transduction
