Background：This gene encodes a member of the STAT-induced STAT inhibitor （SSI）, also known as suppressor of cytokine signaling （SOCS）, family. SSI family members are cytokine-inducible negative regulators of cytokine signaling. The expression of this gene is induced by various cytokines, including IL6, IL10, and interferon （IFN）-gamma. The protein encoded by this gene can bind to JAK2 kinase, and inhibit the activity of JAK2 kinase. Studies of the mouse counterpart of this gene suggested the roles of this gene in the negative regulation of fetal liver hematopoiesis, and placental development.
仕様
Synonyms：ATOD4,CIS 3,CIS-3,CIS3,Cish3,Cytokine induced SH2 protein 3,Cytokine-inducible SH2 protein 3,E2a Pbx1 target gene in fibroblasts 10,EF 10,MGC71791,SOCS 3,SOCS-3,Socs3,SOCS3,SSI 3,SSI-3,SSI3,STAT induced STAT inhibitor 3,STAT-induced STAT inhibitor 3,Suppressor of cytokine signaling 3
Host：Rabbit
Reactivity：Mouse,Rat
Applications：WB
Concentration：1mg/ml
Immunogen：A synthetic peptide of human SOCS3
Purification Method：Affinity purification
Clonality：Polyclonal
Conjugation：Unconjugated
Buffer：Buffer： PBS with 0.02％ sodium azide, 50％ glycerol, pH7.3.
Dilution：WB1：500 - 1：2000
Gene_ID（human）：9021
Swissprot：O14543
Isotype：IgG
Research Areas：Cancer, Epigenetics and Nuclear Signaling, Metabolism, Immunology, Signal transduction, Stem cells
