Background：This gene is a proto-oncogene that encodes a RING finger E3 ubiquitin ligase. The encoded protein is one of the enzymes required for targeting substrates for degradation by the proteasome. This protein mediates the transfer of ubiquitin from ubiquitin conjugating enzymes （E2） to specific substrates. This protein also contains an N-terminal phosphotyrosine binding domain that allows it to interact with numerous tyrosine-phosphorylated substrates and target them for proteasome degradation. As such it functions as a negative regulator of many signal transduction pathways. This gene has been found to be mutated or translocated in many cancers including acute myeloid leukaemia, and expansion of CGG repeats in the 5' UTR has been associated with Jacobsen syndrome. Mutations in this gene are also the cause of Noonan syndrome-like disorder.
仕様
Synonyms：4732447J05Rik,C CBL,Cas Br M （murine） ecotropic retroviral transforming sequence,Casitas B lineage lymphoma proto oncogene,Casitas B-lineage lymphoma proto-oncogene,CBL 2,cbl,CBL,CBL2,E3 ubiquitin protein ligase CBL,E3 ubiquitin-protein ligase CBL,Oncogene CBL2,Proto oncogene c CBL,Proto-oncogene c-CBL,RGD1561386,RING finger protein 55,RNF55,Signal transduction protein CBL
Host：Rabbit
Reactivity：Human,Mouse
Applications：WB,IHC
Concentration：1mg/ml
Immunogen：Recombinant protein of human CBL
Purification Method：Affinity purification
Clonality：Polyclonal
Conjugation：Unconjugated
Dilution：WB1：500 - 1：2000 IHC1：50 - 1：100
Gene_ID（human）：867
Swissprot：P22681
Isotype：IgG
Research Areas：Cancer, Cell Biology, Epigenetics and Nuclear Signaling, Signal transduction
