Background：The gene encodes a member of the integrin alpha chain family of proteins. Integrins are heterodimeric integral membrane proteins composed of an alpha chain and a beta chain that function in cell surface adhesion and signaling. The encoded preproprotein is proteolytically processed to generate light and heavy chains that comprise the alpha 4 subunit. This subunit associates with a beta 1 or beta 7 subunit to form an integrin that may play a role in cell motility and migration. This integrin is a therapeutic target for the treatment of multiple sclerosis, Crohn's disease and inflammatory bowel disease. Alternative splicing results in multiple transcript variants.
仕様
Synonyms：269C wild type,Antigen CD49D,alpha 4 subunit of VLA 4 receptor,CD49 antigen like family member D,CD49 antigen-like family member D,CD49d,IA4,Integrin alpha 4,Integrin alpha 4 subunit,Integrin alpha IV,Integrin alpha-4,Integrin alpha-IV,Integrin,alpha 4 （antigen CD49D,alpha 4 subunit of VLA 4 receptor）,ITA4,ITGA4,MGC90518,OTTHUMP00000205320,Very late activation protein 4 receptor,alpha 4 subunit,VLA 4 subunit alpha,VLA-4 subunit alpha,VLA4
Host：Rabbit
Reactivity：Human,Mouse,Rat
Applications：WB
Concentration：1mg/ml
Immunogen：A synthetic peptide of human ITGA4
Purification Method：Affinity purification
Clonality：Polyclonal
Conjugation：Unconjugated
Buffer：Buffer： PBS with 0.02％ sodium azide, 50％ glycerol, pH7.3.
Dilution：WB1：500 - 1：2000
Gene_ID（human）：3676
Swissprot：P13612
Isotype：IgG
Research Areas：Cancer, Cardiovascular, Immunology, Signal transduction, Stem cells
