Background：This gene encodes a member of the Notch family. Members of this Type 1 transmembrane protein family share structural characteristics including an extracellular domain consisting of multiple epidermal growth factor-like （EGF） repeats, and an intracellular domain consisting of multiple, different domain types. Notch family members play a role in a variety of developmental processes by controlling cell fate decisions. The Notch signaling network is an evolutionarily conserved intercellular signaling pathway which regulates interactions between physically adjacent cells. In Drosophilia, notch interaction with its cell-bound ligands （delta, serrate） establishes an intercellular signaling pathway that plays a key role in development. Homologues of the notch-ligands have also been identified in human, but precise interactions between these ligands and the human notch homologues remain to be determined. This protein is cleaved in the trans-Golgi network, and presented on the cell surface as a heterodimer. This protein functions as a receptor for membrane bound ligands, and may play a role in vascular, renal and hepatic development. Two transcript variants encoding different isoforms have been found for this gene.
仕様
Synonyms：AGS2,hN2,Motch B,N2,N2ECD,N2ICD,neurogenic locus notch homolog protein 2,NOTC2,Notch 2,Notch 2 intracellular domain,Notch Drosophila homolog 2,Notch homolog 2,Notch homolog 2 Drosophila,Notch2
Host：Rabbit
Reactivity：Human,Mouse
Applications：WB,IHC
Concentration：1mg/ml
Immunogen：Recombinant protein of human NOTCH2
Purification Method：Affinity purification
Clonality：Polyclonal
Conjugation：Unconjugated
Buffer：Buffer： PBS with 0.02％ sodium azide, 50％ glycerol, pH7.3.
Dilution：WB1：500 - 1：2000 IHC1：100 - 1：200
Gene_ID（human）：4853
Swissprot：Q04721
Isotype：IgG
Research Areas：Cancer, Epigenetics and Nuclear Signaling, Neuroscience, Stem cells
