Background：The protein encoded by this gene belongs to the caspase recruitment domain （CARD）-containing family of proteins, which are involved in pathways leading to activation of caspases or nuclear factor kappa-B （NFKB）. This protein may be a component of the inflammasome, a protein complex that plays a role in the activation of proinflammatory caspases. It is thought that this protein acts as an adaptor molecule that negatively regulates NFKB activation, CASP1-dependent IL1B secretion, and apoptosis. Polymorphisms in this gene may be associated with a susceptibility to rheumatoid arthritis. Alternatively spliced transcript variants have been described for this gene.
仕様
Synonyms：Apoptotic protein NDPP 1,Apoptotic protein NDPP1,CARD 8,CARD inhibitor of NF kappa B activating ligand,CARD inhibitor of NF kappaB activating ligand,CARD inhibitor of NF kappaB activating ligands,CARD-inhibitor of NF-kappa-B-activating ligand,CARD8,CARD8,CARDINAL,Caspase recruitment domain containing protein 8,Caspase recruitment domain family member 8,Caspase recruitment domain protein 8,Caspase recruitment domain-containing protein 8,DACAR,Dakar,DKFZp779L0366,FLJ18119,FLJ18121,KIAA0955,MGC57162,NDPP 1,NDPP,NDPP1,TUCAN,Tumor up regulated CARD containing antagonist of CASP9,Tumor up regulated CARD containing antagonist of caspase 9,Tumor up-regulated CARD-containing antagonist of CASP9,tumor up-regulated CARD-containing antagonist of caspase nine,Tumor upregulated CARD containing antagonist of CASP9
Host：Rabbit
Reactivity：Human,Mouse,Rat
Applications：WB
Concentration：1mg/ml
Immunogen：Recombinant protein of human CARD8
Purification Method：Affinity purification
Clonality：Polyclonal
Conjugation：Unconjugated
Buffer：Buffer： PBS with 0.02％ sodium azide, 50％ glycerol, pH7.3.
