Background：This receptor binds insulin-like growth factor with a high affinity. It has tyrosine kinase activity. The insulin-like growth factor I receptor plays a critical role in transformation events. Cleavage of the precursor generates alpha and beta subunits. It is highly overexpressed in most malignant tissues where it functions as an anti-apoptotic agent by enhancing cell survival. Alternatively spliced transcript variants encoding distinct isoforms have been found for this gene.
仕様
Synonyms：CD221,CD221 antigen,IGF 1 receptor,IGF 1R,IGF I receptor,IGF-I receptor,Igf1r,IGF1R,IGFIR,IGFIRC,IGFR,Insulin like growth factor 1 receptor,Insulin like growth factor 1 receptor precursor,Insulin-like growth factor 1 receptor beta chain,Insulin-like growth factor I receptor,JTK13,MGC142170,MGC142172,MGC18216,Soluble IGF1R variant 1,Soluble IGF1R variant 2
Host：Rabbit
Reactivity：Human,Mouse
Applications：WB,IHC
Concentration：1mg/ml
Immunogen：A synthetic peptide of human IGF1R
Purification Method：Affinity purification
Clonality：Polyclonal
Conjugation：Unconjugated
Buffer：Buffer： PBS with 0.02％ sodium azide, 50％ glycerol, pH7.3.
Dilution：WB 1：500 - 1：2000 IHC 1：50 - 1：200
Gene_ID（human）：3480
Swissprot：P08069
Isotype：IgG
Research Areas：Cancer, Developmental biology, Signal transduction
