Background：This gene encodes a secreted ligand of the TGF-beta （transforming growth factor-beta） superfamily of proteins. Ligands of this family bind various TGF-beta receptors leading to recruitment and activation of SMAD family transcription factors that regulate gene expression. The encoded preproprotein is proteolytically processed to generate each subunit of the disulfide-linked homodimer, which plays a role in bone and cartilage development. Duplication of a regulatory region downstream of this gene causes a form of brachydactyly characterized by a malformed index finger and second toe in human patients.
仕様
Synonyms：BDA2,BMP-2,BMP-2A,Bmp2,BMP2,BMP2A,Bone morphogenetic protein 2,Bone morphogenetic protein 2A
Host：Rabbit
Reactivity：Human,Mouse,Rat
Applications：WB,IHC
Concentration：1mg/ml
Immunogen：Recombinant protein of human BMP2
Purification Method：Affinity purification
Clonality：Polyclonal
Conjugation：Unconjugated
Dilution：WB1：500 - 1：2000 IHC1：50 - 1：100
Gene_ID（human）：650
Swissprot：P12643
Isotype：IgG
Research Areas：Cancer, Cardiovascular, Signal transduction, Stem cells
