Background:This gene encodes a death agonist that heterodimerizes with either agonist BAX or antagonist BCL2. The encoded protein is a member of the BCL-2 family of cell death regulators. It is a mediator of mitochondrial damage induced by caspase-8 (CASP8); CASP8 cleaves this encoded protein, and the COOH-terminal part translocates to mitochondria where it triggers cytochrome c release. Multiple alternatively spliced transcript variants have been found, but the full-length nature of some variants has not been defined.
仕様
Synonyms:Apoptic death agonist,Apoptotic death agonist BID,BH3 interacting domain death agonist,BH3 interacting domain death agonist p11,BH3 interacting domain death agonist p13,BH3 interacting domain death agonist p15,BH3-interacting domain death agonist p11,BID,BID isoform ES(1b),BID isoform L(2),BID isoform Si6,BID,Desmocollin type 4,FP497,Human BID coding sequence,MGC15319,MGC42355,p11 BID,p13 BID,p15 BID,p22 BID